Christof Fischesser was born in Wiesbaden and studied voice with Martin Gründler (at Hochschule für Musik in Frankfurt am Main). His career took off when he won the first prize at the Bundeswettbewerb Gesang in Berlin.
His first engagement followed at the Badisches Staatstheater Karlsruhe, where he performed many major roles. In 2004, he became a member of the ensemble at the Staatsoper Berlin. He appeared as Rocco (Fidelio) and as Klingsor ( Parsifal), conducted by Daniel Barenboim, as Sarastro (Zauberflöte), Figaro (Le nozze di Figaro), Banquo (Macbeth), Ramfis (Aida), König Marke (Tristan und Isolde), Landgraf (Tannhäuser), Gremin (Eugen Onegin), Escamillo (Carmen), and Don Basilio (Barbiere di Siviglia).
Frequent stations in his career are Bayerische Staatsoper in München, Wiener Staatsoper, Teatro dell Opera in Rome, Covent Garden London, Opera National de Paris, Theatre du Capitole Toulouse, Opera de Lyon or The Grand Theatre de Luxembourg.
From Season 2012/2013 on Fischessers new artistic home will be the Operhouse in Zurich.